Antiviral activity of 9-(2-hydroxyethoxymethyl) guanine against equine herpesvirus type 1 HH-1 strain and pseudorabies virus YS-81 strain.
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منابع مشابه
Antiviral Activity of Arnebia Euchroma and Amniotic Membrane against HSV-1, Rotavirus, and Influenza Virus
Background and Aims: Currently, there are antiviral chemicals used to treat viral infections accompanied by limitations such as high levels of toxicity and adverse effects in humans, the emergence of drug-resistant viral strains, low numbers, and limited diversity. Therefore, it is necessary to evaluate new photochemical to obtain new therapeutic methods. The present study was conducted to eval...
متن کاملThymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
9-(2-Hydroxyethoxymethyl)guanine (acyclo-Guo), is an effective and selective inhibitor of herpes simplex virus replication. This purine nucleoside analogue was found to be phosphorylated at a 30to 120-fold faster rate with extracts of Vero cells infected with herpes simplex virus than with extracts of uninfected cells. The enzyme responsible for this reaction was identified as the virus-coded t...
متن کاملEquine herpesvirus 1 (EHV-1): characterisation of a viral strain isolated from equine plasma in Argentina
Strain "LP-3" of equine herpesvirus 1 (EHV-1), isolated from plasma of horses with clinical signs of rhinopneumonitis, was characterised by cultural, physicochemical, electron microscopic, serological and immunohistochemical studies. This was the first isolation from Argentine horses with respiratory disease. Another strain, SP-1, was isolated in the same laboratory from an aborted fetus in 1980.
متن کاملAntiviral Activity of Obtained Extracts from Different Parts of Cupressus sempervirens against Herpes Simplex Virus Type 1
Objective(s) The aim of this study was to search for new antiviral agents from herbal medicines. Ethanol extracts of C. semipervirens, C. semipervirens var. horizontalis and C. semipervirens cv. Cereiformis were used in experiments to test their influence on herpes viruses (HSV-1). Materials and Methods HeLa cells monolayers were infected with herpes viruses (HSV-1). Antiviral activity of th...
متن کاملEvaluation of Potential Antiviral Activity of the Hydroalcoholic Extract of Lemon Balm L. against Herpes Simplex Virus Type 1
Background and Aims: Lemon Balm L (Lamiaceae) has been used in a variety of practical applications in medical sciences. Its antiviral activity against herpes simplex virus type-1 (HSV-1) was investigated in cell culture. Lemon Balm hydroalcoholic extract was found to be non-toxic to Vero cells up to concentration 800 ug/ml and inhibited the growth and development of HSV-1 in dose-dependent mann...
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ژورنال
عنوان ژورنال: The Japanese Journal of Veterinary Science
سال: 1990
ISSN: 0021-5295,1881-1442
DOI: 10.1292/jvms1939.52.1109